# Chromosome Mutations --- A **chromosome mutation** is a [[mutation]] that occurs on the [[chromosome|chromsomal]] level, including changes in their [[ploidy|number]] or structure. ## Types of Chromosome Mutations ### Deletion Mutation A **deletion mutation** is where a broken segment of a chromosome becomes detached and is lost. ### Inversion Mutation An **inversion mutation** is a where a segment of a chromosome breaks off, flips around and is rejoined. ### Duplication Mutation A **duplication mutation** is a where a segment of a chromosome gets duplicated somehow. This can happen in [[meiosis i|crossing over]] or in [[DNA replication]]. ### Translocation Mutation A **translocation mutation** is a where a broken segment of a chromosome becomes detached and is reattached to a different chromosome entirely. ___